The
Corona
Initiative, PBC

Dedicated to the study and eradication of Coronaviridae

/ Virus Pseudotypes

Virus pseudotypes allow for safe research on Coronaviridae. No BSL-3 facilities are required. The viruses are structurally and functionally identical except they express a reporter gene (Luciferase) instead of viral DNA.

SARS-CoV-2
50ug
SARS-CoV
50ug
MERS-CoV
50ug

/ Neutralization Assays

Have a small molecule or biologic you would like tested for efficacy? Using our pseudovirus we will run viral attachment assays (good for compounds blocking the RBD) and viral entry assays.

/ Complete Virus Genome

NCBI SARS-CoV-2 Complete Genome

View genome

/ Protein Sequences

NCBI SARS-CoV-2 Protein Sequences

View sequences

/ Protein Structures

NCBI SARS-CoV-2 Protein Structures

View structures

/ Study

The Corona Initiative sponsors academic and independent study on Coronaviridae on a gift basis, so long as the collaborator releases their results to the public.

Current focus areas include
Structural determination and computational modeling of virion and viral components, antibodies, and peptides

Virus pseudotyping
Coronovirae epidemiology and systems strategies for complete eradication

/ Media

/ Virus Associated Structures

3D Viewer

6VYB / SARS-CoV-2 spike ectodomain structure (open state)

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Classification: VIRAL PROTEIN
Deposited: 2020-02-25
Released: 2020-03-11
Deposition Author(s): Walls, A.C., Park, Y.J., Tortorici, M.A., Wall, A., Seattle Structural Genomics Center for Infectious Disease (SSGCID), McGuire, A.T., Veesler, D.

3D Viewer

6VXX / Structure of the SARS-CoV-2 spike glycoprotein (closed state)

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Classification: VIRAL PROTEIN
Deposited: 2020-02-25
Released: 2020-03-11
Deposition Author(s): Walls, A.C., Park, Y.J., Tortorici, M.A., Wall, A., Seattle Structural Genomics Center for Infectious Disease (SSGCID), McGuire, A.T., Veesler, D.

3D Viewer

6M17 / The 2019-nCoV RBD/ACE2-B0AT1 complex

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Classification: MEMBRANE PROTEIN/VIRAL PROTEIN
Deposited: 2020-02-24
Released: 2020-03-11
Deposition Author(s): Yan, R.H., Zhang, Y.Y., Li, Y.N., Xia, L., Guo, Y.Y., Zhou, Q.